Calcium-Independent eNOS Activation via HSP90 and AKT

The study reports that (-)-epicatechin can activate eNOS through a calcium-independent pathway involving HSP90 and AKT, offering a plausible endothelial mechanism for vascular benefit.
Cocoa Flavanols and Cardiovascular Event Prevention

The headline result is mixed: null for the primary total-CVD endpoint, but lower CVD death.