GPER Receptor and Endothelial Nitric Oxide Production
The authors report that the effects of (-)-epicatechin in endothelial cells involve GPER, adding a specific receptor-linked explanation for observed vascular signaling responses.
Preeclampsia, Arginase, and Endothelial Protection
This study examined nitric oxide biology and arginase activity in plasma and endothelial cells from women with preeclampsia. It found altered L-arginine/NO signaling and showed that (-)-epicatechin reduced arginase and superoxide-related activity in HUVECs.