Neurological Restorative Effects of (-)-Epicatechin in a Model of Gulf War Illness
This study examined a Gulf War illness model and reported neurological restorative effects with (-)-epicatechin treatment, extending the literature into neurobehavioral and neuroinflammatory contexts.
Stimulatory effects of (−)-epicatechin and its enantiomer (+)-epicatechin on mouse frontal cortex neurogenesis markers and short-term memory: proof of concept
This mouse study compared (-)-epicatechin with its stereoisomer (+)-epicatechin for effects on frontal-cortex-dependent short-term working memory and neurogenesis-related markers. Both compounds increased markers linked to neuronal proliferation, capillary density, nitric-oxide signaling, and memory performance, with (+)-epicatechin generally showing stronger effects.