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Study Title: High Flavonoid Cocoa Supplement Ameliorates Plasma Oxidative Stress and Inflammation Levels While Improving Mobility and Quality of Life in Older Subjects: A Double-Blind Randomized Clinical Trial
Citation: Munguia et al., 2019 · The Journals of Gerontology Series A
What the Study Found: Researchers conducted a two-phase randomized, double-blind trial of a flavonoid-rich cocoa beverage in middle-aged and older adults. The first phase enrolled 60 people aged 55–70 across placebo, low-flavonoid cocoa and high-flavonoid cocoa groups; a subsequent phase involved 74 adults aged 65–90 comparing two cocoa formulations. The beverages were consumed daily for up to 12 weeks. The authors reported favorable differences in selected blood oxidative-stress, inflammatory and metabolic markers, physical-performance measures and quality-of-life scores. The intervention contained a mixture of cocoa flavanols, including approximately 25 mg (−)-epicatechin per flavonoid-rich serving, rather than purified epicatechin. Mitochondrial function was not directly tested.
What this means in real life: This controlled trial supports further investigation of cocoa flavanol beverages for selected aging-related biomarkers and physical-performance measures. It does not establish that isolated (−)-epicatechin produced those effects or directly preserved mitochondrial function. Differences in study phases, sample sizes and duration also limit claims about prevention of frailty, disability or long-term disease.
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