Oxidative Stress, Inflammation, and Mobility in Older Adults
In older adults, regular high-flavonoid cocoa intake improved oxidative stress, inflammation, physical performance, and quality-of-life measures.
NASHにおけるペリリピンの発現と肝臓の脂肪代謝
本研究では、食事誘発性NASHモデルを用いて、ペリリピンの発現の経時的な変化を追跡し、(-)-epicatechin 時間経過とともにこれらの脂質滴に関連する反応をどのように(-)-epicatechin 評価した。
(-)-Epicatechinに対する細胞膜シグナル伝達と内皮細胞の反応
本論文は、(-)-epicatechin 細胞表面受容体を介したメカニズムを通じて内皮細胞のシグナル伝達を誘導(-)-epicatechin 示しており、単なる細胞内での抗酸化作用だけでなく、膜を起点とするシグナル伝達も支持するものである。
Beneficial Effects of Flavonoids on Skeletal Muscle Health: A Systematic Review and Meta-Analysis
Skeletal muscle (SkM) is a highly dynamic tissue that responds to physiological adaptations or pathological conditions, and SkM mitochondria play a major role in bioenergetics, regulation of intracellular calcium homeostasis, pro-oxidant/antioxidant balance, and apoptosis. Flavonoids are polyphenolic compounds with the ability to modulate molecular pathways implicated in the development of mitochondrial myopathy. Therefore, it is pertinent to explore its potential application in conditions such as aging, disuse, denervation, diabetes, obesity, and cancer. To evaluate preclinical and clinical effects of flavonoids on SkM structure and function. We performed a systematic review of published studies, with no date restrictions applied, using PubMed and Scopus. The following search terms were used: “flavonoids” OR “flavanols” OR “flavones” OR “anthocyanidins” OR “flavanones” OR “flavan-3-ols” OR “catechins” OR “epicatechin” OR “(−)-epicatechin” AND “skeletal muscle.” The studies included in this review were preclinical studies, clinical trials, controlled clinical trials, and randomized-controlled trials that investigated the influence of flavonoids on SkM health. Three authors, independently, assessed trials for the review. Any disagreement was resolved by consensus. The use of flavonoids could be a potential tool for the prevention of muscle loss. Their effects on metabolism and on mitochondria function suggest their use as muscle regulators.