(-)-Epicatechin rich cocoa mediated modulation of oxidative stress regulators in skeletal muscle of heart failure and type 2 diabetes patients
In patients with heart failure and type 2 diabetes, (-)-epicatechin-rich cocoa modulated oxidative-stress regulators in skeletal muscle, supporting an effect on redox biology in clinically relevant tissue.
Perturbations in skeletal muscle sarcomere structure in patients with heart failure and Type 2 diabetes: restorative effects of (−)-epicatechinrich cocoa
This clinical study found structural sarcomere abnormalities in skeletal muscle from patients with heart failure and type 2 diabetes, and reported restorative effects after (-)-epicatechin-rich cocoa intake.
(-)-Epicatechin induces mitochondrial biogenesis and markers of muscle regeneration in adults with Becker muscular dystrophy
In adults with Becker muscular dystrophy, (-)-epicatechin increased markers of mitochondrial biogenesis and muscle regeneration, suggesting a potentially relevant biological response in a human neuromuscular condition.