A randomized, placebo-controlled, double-blind study on the effects of (−)-epicatechin on the triglyceride/HDLc ratio and cardiometabolic profile of subjects with hypertriglyceridemia: Unique in vitro effects
Randomized, double-blind placebo-controlled trial in people with hypertriglyceridemia. The study reported preliminary favorable effects on glycemic homeostasis, lipid profile, and systemic inflammation, with parallel in vitro findings suggesting pathway-specific rather than generic antioxidant effects.
Acute effects of an oral supplement of (-)-epicatechin on postprandial fat and carbohydrate metabolism in normal and overweight subjects
This human study assessed short-term metabolic effects of an oral (-)-epicatechin supplement after meals, reporting changes in postprandial fat and carbohydrate handling in normal and overweight participants.
Effects of (−)-epicatechin on the time course of the expression of perilipins in a diet-induced model of nonalcoholic steatohepatitis
Using a diet-induced NASH model, this study tracked the time course of perilipin expression and assessed how (-)-epicatechin altered those lipid-droplet–related responses over time.