Peer-Reviewed Papers

Explore published research on mitochondrial function, cellular energy, (-)-epicatechin, vascular biology, and related metabolic pathways. Browse by specialization below to quickly find the papers most relevant to your interests.

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(-)-Epicatechin rich cocoa mediated modulation of oxidative stress regulators in skeletal muscle of heart failure and type 2 diabetes patients

Ramírez-Sánchez et al., 2013 · International Journal of Cardiology
In patients with heart failure and type 2 diabetes, (-)-epicatechin-rich cocoa modulated oxidative-stress regulators in skeletal muscle, supporting an effect on redox biology in clinically relevant tissue.

Perturbations in skeletal muscle sarcomere structure in patients with heart failure and Type 2 diabetes: restorative effects of (−)-epicatechinrich cocoa 

Taub et al., 2013 · Clinical Science
This clinical study found structural sarcomere abnormalities in skeletal muscle from patients with heart failure and type 2 diabetes, and reported restorative effects after (-)-epicatechin-rich cocoa intake.

(-)-Epicatechin induces mitochondrial biogenesis and markers of muscle regeneration in adults with Becker muscular dystrophy

McDonald et al., 2021 · Muscle & Nerve
In adults with Becker muscular dystrophy, (-)-epicatechin increased markers of mitochondrial biogenesis and muscle regeneration, suggesting a potentially relevant biological response in a human neuromuscular condition.

(–)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle

Nogueira et al., 2011 · The Journal of Physiology
This animal study found that (-)-epicatechin improved fatigue resistance and oxidative capacity in mouse muscle, supporting a mitochondrial or oxidative-metabolism effect in skeletal muscle.

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