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    Peer-Reviewed Papers

    Explore published research on mitochondrial function, cellular energy, (-)-epicatechin, vascular biology, and related metabolic pathways. Browse by specialization below to quickly find the papers most relevant to your interests.

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    Effect of (-)-epicatechin on the modulation of progression markers of chronic renal damage in a 5/6 nephrectomy experimental model

    Montes-Rivera et al., 2019 · Heliyon
    In a 5/6 nephrectomy model, this study evaluated whether (-)-epicatechin altered biomarkers linked to progression of chronic renal damage, reporting modulation of disease-relevant markers.
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    Neurological Restorative Effects of (-)-Epicatechin in a Model of Gulf War Illness

    Ramírez-Sánchez et al., 2024 · Journal of Medicinal Food
    This study examined a Gulf War illness model and reported neurological restorative effects with (-)-epicatechin treatment, extending the literature into neurobehavioral and neuroinflammatory contexts.
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    Effects of (−)-epicatechin on neuroinflammation and hyperphosphorylation of tau in the hippocampus of aged mice

    Navarrete-Yañez et al., 2020 · Food & Function
    In aged mice, (-)-epicatechin reduced oxidative stress, neuroinflammation, and tau hyperphosphorylation in the hippocampus, while also improving several behavioral and inflammatory measures.
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    Stimulatory effects of (−)-epicatechin and its enantiomer (+)-epicatechin on mouse frontal cortex neurogenesis markers and short-term memory: proof of concept

    Navarrete-Yañez et al., 2021 · Food & Function
    This mouse study compared (-)-epicatechin with its stereoisomer (+)-epicatechin for effects on frontal-cortex-dependent short-term working memory and neurogenesis-related markers. Both compounds increased markers linked to neuronal proliferation, capillary density, nitric-oxide signaling, and memory performance, with (+)-epicatechin generally showing stronger effects.
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    Effects of (−)-epicatechin on frontal cortex DAPC and dysbindin of the mdx mice

    Estrada-Mena et al., 2017 · Neuroscience Letters
    This study evaluated whether (-)-epicatechin could restore dystrophin-associated protein complex (DAPC) components and dysbindin in the prefrontal cortex of mdx mice, a model of Duchenne muscular dystrophy. After four weeks of treatment, (-)-epicatechin partially recovered multiple DAPC-related proteins and associated interactions, suggesting a shift toward a healthier brain protein profile.
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