Neuroinflammation, Tau Pathology, and Brain Aging
In aged mice, (-)-epicatechin reduced oxidative stress, neuroinflammation, and tau hyperphosphorylation in the hippocampus, while also improving several behavioral and inflammatory measures.
Neurogenesis, Short-Term Memory, and Nitric Oxide Signaling
This mouse study compared (-)-epicatechin with its stereoisomer (+)-epicatechin for effects on frontal-cortex-dependent short-term working memory and neurogenesis-related markers. Both compounds increased markers linked to neuronal proliferation, capillary density, nitric-oxide signaling, and memory performance, with (+)-epicatechin generally showing stronger effects.
Estructura de las proteínas cerebrales y estabilidad celular
Este estudio evaluó si (-)-epicatechin restaurar los componentes del complejo proteico asociado a la distrofina (DAPC) y la disbindina en la corteza prefrontal de ratones mdx, un modelo de distrofia muscular de Duchenne. Tras cuatro semanas de tratamiento, (-)-epicatechin recuperó (-)-epicatechin múltiples proteínas relacionadas con el DAPC y las interacciones asociadas, lo que sugiere un cambio hacia un perfil proteico cerebral más saludable.
Epicatechin and Breast Cancer Cell Migration in Vitro
This in vitro study found that (-)-epicatechin reduced proliferation, migration, and invasion markers in murine breast cancer cells under experimental conditions.