Chocolate negro, epicatequina y energía celular
El chocolate suele consumirse por su sabor, pero las investigaciones sobre el cacao apuntan a algo más profundo. Descubre cómo se ha estudiado la epicatequina por su papel en el apoyo a la forma en que las células producen y gestionan la energía.
¿Qué les pasa a tus mitocondrias cuando no duermes lo suficiente?
Ya sabes que dormir es esencial para tu cerebro y tu estado de ánimo, pero ¿sabías que también es fundamental para tus mitocondrias?
Where Energy, Science, and Community Come Together – Mitozz Community
We’re excited to announce that on Lunes, octubre 20th, we officially launched the Mitozz Community, a new digital home for people who want to understand, explore, and share everything about mitochondrial health, cellular energy, and vitality.
How Does Mitochondrial Health Define Your Body? The Real Story of Energy from Within
We often hear that “food gives us energy,” but the truth is a little more complex and a lot more fascinating. The real powerhouses behind your energy are tiny structures inside your cells called mitochondria.
Mitochondrial Biogenesis and Oxidative Stress in Aging
In senile mice, (-)-epicatechin restored markers linked to mitochondrial biogenesis and improved oxidative-stress and aging-related indicators.
Skeletal Muscle Mitochondrial Structure in Type 2 Diabetes and Heart Failure
This clinical study reported improved skeletal-muscle mitochondrial structure and increased markers of mitochondrial biogenesis after epicatechin-rich cocoa in patients with type 2 diabetes and heart failure.
Mitochondrial Biogenesis in Muscle Cells via GPER
In C2C12 myotubes, (-)-epicatechin stimulated mitochondrial biogenesis and cell growth, and the study implicated the G-protein–coupled estrogen receptor in that response.
Postprandial Fat Oxidation and Epicatechin
This human study assessed short-term metabolic effects of an oral (-)-epicatechin supplement after meals, reporting changes in postprandial fat and carbohydrate handling in normal and overweight participants.
Exercise Capacity, Dark Chocolate, and Mitochondrial Efficiency
In sedentary adults, dark chocolate intake improved exercise-related performance measures, including work achieved and VO2 max trends, with mechanistic data pointing toward mitochondrial efficiency and upstream signaling changes.
(-)-Epicatechin-induced recovery of mitochondria from simulated diabetes: Potential role of endothelial nitric oxide synthase
(-)-Epicatechin increases indicators associated with mitochondrial biogenesis in endothelial cells and myocardium. We investigated endothelial nitric oxide synthase involvement on (-)-epicatechin-induced increases in indicators associated with mitochondrial biogenesis in human coronary artery endothelial cells cultured in normal-glucose and high-glucose media, as well as to restore indicators of cardiac mitochondria from the effects of simulated diabetes. Here, we demonstrate the role of endothelial nitric oxide synthase on (-)-epicatechin-induced increases in mitochondrial proteins, transcription factors and sirtuin 1 under normal-glucose conditions. In simulated diabetes endothelial nitric oxide synthase function, mitochondrial function–associated and biogenesis-associated indicators were adversely impacted by high glucose, effects that were reverted by (-)-epicatechin. As an animal model of type 2 diabetes, 2-month old C57BL/6 mice were fed a high-fat diet for 16 weeks. Fasting and fed blood glucose levels were increased and NO plasma levels decreased. High-fat-diet-fed mice myocardium revealed endothelial nitric oxide synthase dysfunction, reduced mitochondrial activity and markers of mitochondrial biogenesis. The administration of 1 mg/kg (-)-epicatechin for 15 days by oral gavage shifted these endpoints towards control mice values. Results suggest that endothelial nitric oxide synthase mediates (-)-epicatechin-induced increases of indicators associated with mitochondrial biogenesis in endothelial cells. (-)-Epicatechin also counteracts the negative effects that high glucose or simulated type 2 diabetes has on endothelial nitric oxide synthase function.
White Fat Browning and Mitochondrial Biogenesis in Adipose Tissue
This study found that (-)-epicatechin promoted browning-related changes in adipocytes and white adipose tissue, with associated improvements in mitochondrial function and thermogenic markers.
Mitochondrial Biogenesis, Muscle Regeneration, and Human Neuromuscular Disease
In adults with Becker muscular dystrophy, (-)-epicatechin increased markers of mitochondrial biogenesis and muscle regeneration, suggesting a potentially relevant biological response in a human neuromuscular condition.