Sleep and Mitochondria: The Nightly Repair Cycle That Powers Your Day
You already know that sleep is essential for your brain and mood but did you know it’s also critical for your mitochondria?
Where Energy, Science, and Community Come Together – Mitozz Community
We’re excited to announce that on Monday, October 20th, we officially launched the Mitozz Community, a new digital home for people who want to understand, explore, and share everything about mitochondrial health, cellular energy, and vitality.
How Does Mitochondrial Health Define Your Body? The Real Story of Energy from Within
We often hear that “food gives us energy,” but the truth is a little more complex and a lot more fascinating. The real powerhouses behind your energy are tiny structures inside your cells called mitochondria.
What Is Mitochondrial Function and Why Is It Key to Your Health?
If you’ve ever felt low on energy despite sleeping well and eating right, the issue might not be your lifestyle, the issue might be what’s happening inside your cells. More specifically: inside your mitochondria.
Mitochondrial Biogenesis and Oxidative Stress in Aging
In senile mice, (-)-epicatechin restored markers linked to mitochondrial biogenesis and improved oxidative-stress and aging-related indicators.
Mitochondrial Biogenesis in Muscle Cells via GPER
In C2C12 myotubes, (-)-epicatechin stimulated mitochondrial biogenesis and cell growth, and the study implicated the G-protein–coupled estrogen receptor in that response.
Apelin Receptor Signaling and Biased Agonism
This paper identifies (-)-epicatechin as a biased ligand of the apelin receptor, supporting a receptor-mediated signaling mechanism that may help explain some of its vascular and metabolic effects.
eNOS Activation and Nitric Oxide Signaling Pathways
This study found that (-)-epicatechin activates endothelial nitric oxide synthase and increases nitric oxide signaling in endothelial cells, helping define a plausible endothelial mechanism for vascular benefit.
GPER Receptor and Endothelial Nitric Oxide Production
The authors report that the effects of (-)-epicatechin in endothelial cells involve GPER, adding a specific receptor-linked explanation for observed vascular signaling responses.
Postprandial Fat Oxidation and Epicatechin
This human study assessed short-term metabolic effects of an oral (-)-epicatechin supplement after meals, reporting changes in postprandial fat and carbohydrate handling in normal and overweight participants.
Perilipin Expression and Liver Fat Metabolism in NASH
Using a diet-induced NASH model, this study tracked the time course of perilipin expression and assessed how (-)-epicatechin altered those lipid-droplet–related responses over time.
Endothelial Cell Aging Reversal and Vascular Function
This paper reports that (-)-epicatechin reversed several features of endothelial cell aging and improved vascular function, while also exploring the mechanisms behind those changes.